Management of Diabetic ketoacidosis: Role of Rapid Acting Insulin Analogs in comparison to regular intravenous insulin.

Background: Diabetic ketoacidosis (DKA) is an acute metabolic healthcare crisis in patients with diabetes mellitus. The current study aimed to compare the effectiveness of rapid-acting insulin analog administered subcutaneously regular infused intravenously among DKA patients. Methodology: In this prospective open labelled study, 100 consecutive were randomly assigned two groups. Group 1 admitted intensive care unit (ICU) and treated intravenous infusion. 2 managed emergency medical ward subcutaneous insulin. Response therapy was assessed by follow-up investigations biochemical parameters, including blood glucose concentration, serum ketones, pH, electrolytes bicarbonates, sodium potassium concentration until resolution DKA. Furthermore, overall duration (blood level < 250 mg/dl), time amount DKA, also assessed. Results: The baseline clinical parameters similar between treatment groups except for concentration. mean random sugar (RBS), acid-base ketone bodies significantly improved from admission There no significant difference (p=0.07). While required reduced insulin, i.e. 16.36 ± 6.92 hrs 59.28 30.05 units (p<0.05). Conclusion: less complicated can be wards obviating need ICU. With relatively better outcomes, it effective alternative infusion resolution.